Effect of Phenylbutazone, Flunixin Meglumine and Firocoxib onex vivoCyclo-Oxygenase Activity in Horses Undergoing Elective Surgery

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Phenylbutazone and flunixin meglumine used singly or in combination in experimental lameness in horses.

REASON FOR PERFORMING STUDY Using an adjustable heart bar shoe model of foot pain, the objective of this study was to test the hypothesis that the combined use of phenylbutazone (PBZ) and flunixin meglumine (FM) would prove more efficacious in alleviating lameness than either drug alone. MATERIALS AND METHODS One hour after induction of lameness at weekly intervals, 8 healthy adult Thoroughbr...

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Fasting duration in patients undergoing elective surgery

Background and Purpose: Preoperative fast is the essential part of preoperative care for those patients who are candidates for elective surgery. Fast prolongation results in side effects such as: sweating, irritability, decrease in blood sugar and restlessness. Despite the noticeable changes in fasting guidelines and their application in many countries, it seems that in Iran, these rules are no...

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Toxicity of Flunixin Meglumine in Broiler Chickens

This study was designed to evaluate the toxicity of flunixin meglumine, a nonsteroidal anti-inflammatory drug which might serve as an alternate of diclofenac that has been shown to cause toxicity in vultures. Twenty five broiler chickens of five weeks of age were randomly divided into five equal groups and treated with flunixin meglumine at the dosage rate of 0, 1.25, 2.5, 5 and 10 mg/kg body w...

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Pharmacokinetic interactions of flunixin meglumine and enrofloxacin in ICR mice.

We examined the pharmacokinetic interactions of enrofloxacin and flunixin in male ICR mice that were subcutaneously (SC) administered with both or either one of the drugs. The experiments were performed on the following three groups: flunixin alone (2 mg/kg, SC), combination of flunixin (2 mg/kg, SC) and enrofloxacin (10 mg/kg, SC), and enrofloxacin alone (10 mg/kg, SC). Blood samples were coll...

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Effect of intracerebroventricular injection of flunixin meglumine on PTZ-induced seizures in male rats

Introduction: Flunixin Meglumine (FM) is a nonsteroidal antiinflammatory drug (NSAID) and nonselective cyclooxygenase (COX) inhibitor. Since it has been suggested that COX enzyme plays a role in seizure, this research is performed to assess the therapeutic effects that this compound might have in seizures induced by PTZ. Methods: In this research, male wistar rats (200 ± 20 g) were given int...

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ژورنال

عنوان ژورنال: Equine Veterinary Journal

سال: 2013

ISSN: 0425-1644

DOI: 10.1111/evj.12145_36